Lodestar

WVE

Wave Life Sciences, Inc.
NasdaqPharmaceutical PreparationsLatest fiscal year ended Dec 31, 2025

Wave Life Sciences, Inc. reported revenue of $42.73M in its most recent fiscal year, down 60.5% on the year before. It kept -478.3% of that as net income, and generated -$188.21M of free cash flow. Figures below are compared against other companies classified under Pharmaceutical Preparations.

Grades vs. industry

Growth
C+56/100
Ranked against 169 peers using 3 metrics.
Profitability
D30/100
Ranked against 156 peers using 5 metrics.

Growth

MetricCompanyIndustry medianRank
Revenue growth (YoY)
Latest fiscal year revenue vs. the year before.
-60.5%7.4%188 / 219
Revenue growth (3y)
Annualized revenue growth over three fiscal years.
127.1%7.6%16 / 186
Revenue growth (5y)
Annualized revenue growth over five fiscal years.
16.3%7.3%63 / 169
EPS growth (YoY)
Diluted EPS vs. the prior fiscal year.
Not reported-33.3%—
EPS growth (3y)
Annualized diluted EPS growth over three fiscal years.
Not reported4.0%—
EPS growth (5y)
Annualized diluted EPS growth over five fiscal years.
Not reported3.8%—
Free cash flow growth (YoY)
Operating cash flow less capital expenditure, vs. prior year.
Not reported-7.9%—
Free cash flow growth (3y)
Annualized free cash flow growth over three fiscal years.
Not reported1.4%—

top third of peersmiddle thirdbottom third. Rank 1 is always best — for debt and payout ratios that means the lowest figure, not the highest.

“Not reported” means the company did not tag this figure in its filing, not that the value is zero. Rankings are hidden where fewer than 5 classified peers reported the metric, and compare against a broad industry code rather than close competitors.

Profitability

MetricCompanyIndustry medianRank
Gross margin
Gross profit as a share of revenue. Often unreported.
Not reported72.1%—
Operating margin
Operating income as a share of revenue.
-504.1%-34.2%142 / 163
Net margin
Net income as a share of revenue.
-478.3%-30.0%154 / 173
Free cash flow margin
Free cash flow as a share of revenue.
-440.5%-15.3%135 / 156
Return on equity
Net income divided by shareholder equity.
-39.4%-52.3%158 / 368
Return on assets
Net income divided by total assets.
-32.0%-37.6%185 / 419
Return on invested capital
After-tax operating profit over debt plus equity less cash.
Not reported-49.3%—

top third of peersmiddle thirdbottom third. Rank 1 is always best — for debt and payout ratios that means the lowest figure, not the highest.

“Not reported” means the company did not tag this figure in its filing, not that the value is zero. Rankings are hidden where fewer than 5 classified peers reported the metric, and compare against a broad industry code rather than close competitors.

Financial health

MetricCompanyIndustry medianRank
Debt to equity
Total debt divided by shareholder equity.
Not reported0.24x—
Current ratio
Current assets over current liabilities.
6.47x4.17x147 / 419
Quick ratio
Current assets excluding inventory, over current liabilities.
6.47x3.84x145 / 419
Interest coverage
Operating income divided by interest expense.
Not reported-15.21x—
Net debt to EBITDA
Net debt over derived EBITDA. EBITDA is not a GAAP tag; it is computed.
Not reported-1.56x—

top third of peersmiddle thirdbottom third. Rank 1 is always best — for debt and payout ratios that means the lowest figure, not the highest.

“Not reported” means the company did not tag this figure in its filing, not that the value is zero. Rankings are hidden where fewer than 5 classified peers reported the metric, and compare against a broad industry code rather than close competitors.

Insider activity

Trades reported by officers, directors and 10% shareholders on SEC Form 4. None of the last 22 reported transactions were open-market purchases — grants, option exercises and sales make up the majority of insider filings at most companies.

DateInsiderTransactionSharesPriceValue
Oct 5, 2026
CORRIGAN MARK
Director
Grant or award10,700$0.00$0.00
Oct 5, 2026
CORRIGAN MARK
Director
Grant or award(derivative)64,000$0.00$0.00
Oct 5, 2026
HENRY CHRISTIAN O
Director
Grant or award10,700$0.00$0.00
Oct 5, 2026
HENRY CHRISTIAN O
Director
Grant or award(derivative)64,000$0.00$0.00
Oct 5, 2026
RA CAPITAL MANAGEMENT, L.P., RA Capital Healthcare Fund LP, Kolchinsky Peter, Shah Rajeev M.
Director, 10% owner
Grant or award10,700$0.00$0.00
Oct 5, 2026
RA CAPITAL MANAGEMENT, L.P., RA Capital Healthcare Fund LP, Kolchinsky Peter, Shah Rajeev M.
Director, 10% owner
Grant or award(derivative)64,000$0.00$0.00
Oct 5, 2026
Rawcliffe Adrian
Director
Grant or award10,700$0.00$0.00
Oct 5, 2026
Rawcliffe Adrian
Director
Grant or award(derivative)64,000$0.00$0.00
Oct 5, 2026
Verdine Gregory L.
Director
Grant or award10,700$0.00$0.00
Oct 5, 2026
Verdine Gregory L.
Director
Grant or award(derivative)64,000$0.00$0.00
Oct 5, 2026
Wagner Heidi L
Director
Grant or award10,700$0.00$0.00
Oct 5, 2026
Wagner Heidi L
Director
Grant or award(derivative)64,000$0.00$0.00
Oct 5, 2026
TAKANASHI KEN
Director
Grant or award10,700$0.00$0.00
Oct 5, 2026
TAKANASHI KEN
Director
Grant or award(derivative)64,000$0.00$0.00
Oct 5, 2026
Tan Aik Na
Director
Grant or award10,700$0.00$0.00
Oct 5, 2026
Tan Aik Na
Director
Grant or award(derivative)64,000$0.00$0.00
Aug 12, 2026
Rawcliffe Adrian
Director
Open-market sale12,700$5.29$67.2K
Aug 11, 2026
Wagner Heidi L
Director
Open-market sale7,000$6.01$42.1K
Aug 11, 2026
Wagner Heidi L
Director
Option exercise7,000$5.97$41.8K
Aug 11, 2026
TAKANASHI KEN
Director
Open-market sale3,864$6.01$23.2K
Aug 11, 2026
Tan Aik Na
Director
Open-market sale432$6.01$2.6K
Aug 11, 2026
Wagner Heidi L
Director
Option exercise(derivative)7,000$0.00$0.00

A dash under price or value means none was reported, which is normal for grants and gifts — it does not mean the shares were free. Option exercises and awards are compensation arriving on a schedule, not a judgement about the stock.

Annual financials

Fiscal year2025202420232022202120202019201820172016
Revenue$42.73M$108.30M$113.31M$3.65M$40.96M$20.08M$15.98M$14.41M$3.70M$1.49M
Operating income-$215.38M-$110.40M-$68.00M-$162.72M-$127.02M-$153.38M-$208.32M-$159.52M-$102.39M-$55.72M
Net income-$204.38M-$97.01M-$57.51M-$161.82M-$122.25M-$149.91M-$193.64M-$146.65M-$101.98M-$55.66M
EPS (diluted)-$1.21-$0.70-$0.54-$2.05-$2.36-$3.82-$5.72-$5.06-$3.85-$2.44
Operating cash flow-$187.49M-$151.03M-$19.43M-$127.78M-$88.99M-$115.98M-$188.23M-$22.86M-$83.67M-$31.93M
Capital expenditure$718.0K$938.0K$1.11M$1.36M$560.0K$1.34M$3.92M$9.94M$18.89M$5.57M
Free cash flow-$188.21M-$151.96M-$20.55M-$129.14M-$89.55M-$117.32M-$192.15M-$32.80M-$102.56M-$37.49M
Total assets$638.50M$352.21M$274.95M$146.39M$207.01M$279.24M$284.25M$295.94M$181.84M$164.81M
Shareholder equity$518.36M$209.51M$39.63M-$45.09M$32.50M$82.78M$63.73M$73.35M$139.61M$134.60M
Cash$602.07M$302.08M$200.35M$88.50M$150.56M$184.50M$147.16M$174.82M$142.50M$150.29M

A dash means the figure was not tagged in that year’s filing. It does not mean zero. Figures reflect the most recent filing covering each period, so restated years show their restated values.

Source

Figures come from Wave Life Sciences, Inc.’s filings with the SEC, as submitted in XBRL. The most recent annual figures are from a 10-K filed Feb 26, 2026. View filings on EDGAR.

Not financial advice. This page presents figures reported to the SEC and compares them with other companies sharing an industry classification. It is not a recommendation to buy or sell anything, and the grades cannot capture everything that matters about a business. Industry classifications are coarse, filings are self-reported, and some figures are missing or understated where companies tag them in ways this site does not match. Do your own research.